abstract：:Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....

journal_title：Cells

authors： Tikhomirov R,Donnell BR,Catapano F,Faggian G,Gorelik J,Martelli F,Emanueli C

更新日期：2020-03-02 00:00:00

abstract：:The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...

journal_title：Cells

authors： Albakova Z,Armeev GA,Kanevskiy LM,Kovalenko EI,Sapozhnikov AM

更新日期：2020-03-02 00:00:00

abstract：:BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...

journal_title：Cells

authors： Kögel D,Linder B,Brunschweiger A,Chines S,Behl C

更新日期：2020-02-28 00:00:00

abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

journal_title：Cells

authors： Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

更新日期：2020-02-26 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...

journal_title：Cells

authors： Stochaj U,Weber SC

更新日期：2020-02-25 00:00:00

abstract：:Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...

journal_title：Cells

authors： Mélik Parsadaniantz S,Réaux-le Goazigo A,Sapienza A,Habas C,Baudouin C

更新日期：2020-02-25 00:00:00

abstract：:Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

journal_title：Cells

authors： Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

更新日期：2020-02-24 00:00:00

abstract：:The zygote is defined as a diploid cell resulting from the fusion of two haploid gametes. Union of haploid male and female pronuclei in many animals occurs through rearrangements of the microtubule cytoskeleton into a radial array of microtubules known as the sperm aster. The sperm aster nucleates from paternally-deri...

journal_title：Cells

authors： Meaders JL,Burgess DR

更新日期：2020-02-23 00:00:00

abstract：:The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...

journal_title：Cells

authors： Wai KC,Strohl MP,van Zante A,Ha PK

更新日期：2020-02-22 00:00:00

abstract：:Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed for regenerative medicine, cardiovascular research, and pharmacological studies. However, the differentiation of adult MSC into a cardiac lineage is challenging compared to ...

journal_title：Cells

authors： Mueller P,Wolfien M,Ekat K,Lang CI,Koczan D,Wolkenhauer O,Hahn O,Peters K,Lang H,David R,Lemcke H

更新日期：2020-02-22 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

journal_title：Cells

authors： Frey K,Pucker B

更新日期：2020-02-18 00:00:00

abstract：:Autoimmune rheumatic diseases (ARDs), affecting ~1-1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, ...

journal_title：Cells

authors： Bank I

更新日期：2020-02-18 00:00:00

abstract：:Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...

journal_title：Cells

authors： Raasakka A,Kursula P

更新日期：2020-02-18 00:00:00

abstract：:The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key proteins that generate (beta-secretase 1...

journal_title：Cells

authors： Buniatian GH,Weiskirchen R,Weiss TS,Schwinghammer U,Fritz M,Seferyan T,Proksch B,Glaser M,Lourhmati A,Buadze M,Borkham-Kamphorst E,Gaunitz F,Gleiter CH,Lang T,Schaeffeler E,Tremmel R,Cynis H,Frey WH 2nd,Gebhardt R,F

更新日期：2020-02-17 00:00:00

abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...

journal_title：Cells

authors： Cheng X,Li L,Shi G,Chen L,Fang C,Li M,Li C

更新日期：2020-02-15 00:00:00

abstract：:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyc...

journal_title：Cells

authors： Karwowski BT

更新日期：2020-02-12 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...

journal_title：Cells

authors： Saccenti L,Hagiwara A,Andica C,Yokoyama K,Fujita S,Kato S,Maekawa T,Kamagata K,Le Berre A,Hori M,Wada A,Tateishi U,Hattori N,Aoki S

更新日期：2020-02-08 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanisms involved in the neurodegenerative process in ALS have been found, ...

journal_title：Cells

authors： Vicencio E,Beltrán S,Labrador L,Manque P,Nassif M,Woehlbier U

更新日期：2020-02-07 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...

journal_title：Cells

authors： Plesner T,van de Donk N,Richardson PG

更新日期：2020-02-06 00:00:00

abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

journal_title：Cells

authors： Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

更新日期：2020-02-06 00:00:00

abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

journal_title：Cells

authors： Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

更新日期：2020-02-05 00:00:00

abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

journal_title：Cells

authors： Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

更新日期：2020-02-04 00:00:00

abstract：:Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...

journal_title：Cells

authors： Amir M,Khan P,Queen A,Dohare R,Alajmi MF,Hussain A,Islam A,Ahmad F,Hassan I

更新日期：2020-02-04 00:00:00

abstract：:Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...

journal_title：Cells

authors： Sioud F,Amor S,Toumia IB,Lahmar A,Aires V,Chekir-Ghedira L,Delmas D

更新日期：2020-02-04 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs f...

journal_title：Cells

authors： Xi Y,Zhang Y,Zhu S,Luo Y,Xu P,Huang Z

更新日期：2020-02-03 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

journal_title：Cells

authors： Rolot M,O'Sullivan TE

更新日期：2020-02-01 00:00:00

abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...

journal_title：Cells

authors： Riboni L,Abdel Hadi L,Navone SE,Guarnaccia L,Campanella R,Marfia G

更新日期：2020-02-01 00:00:00

abstract：:Fatty acids are the main respiratory substrates important for cardiac function, and their oxidation is altered during various chronic disorders. We investigated the mechanism of fatty acid-oxidation-induced changes and their relations with mitochondrial morphology and ADP/ATP carrier conformation on the kinetics of th...

journal_title：Cells

authors： Toleikis A,Trumbeckaite S,Liobikas J,Pauziene N,Kursvietiene L,Kopustinskiene DM

更新日期：2020-02-01 00:00:00

abstract：:Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...

journal_title：Cells

authors： Merckx G,Hosseinkhani B,Kuypers S,Deville S,Irobi J,Nelissen I,Michiels L,Lambrichts I,Bronckaers A

更新日期：2020-01-28 00:00:00

abstract：:Cancer frequency and prevalence have been increasing in the past decades, with devastating impacts on patients and their families. Despite the great advances in targeted approaches, there is still a lack of methods to predict individual patient responses, and therefore treatments are tailored according to average resp...

journal_title：Cells

authors： Costa B,Estrada MF,Mendes RV,Fior R

更新日期：2020-01-25 00:00:00

abstract：:During embryonic development, the heart undergoes complex morphogenesis from a liner tube into the four chambers consisting of ventricles, atria and valves. At the same time, the cardiomyocytes compact into a dense, aligned, and highly vascularized myocardium. The extracellular matrix (ECM) is known to play an importa...

journal_title：Cells

authors： Jallerat Q,Feinberg AW

更新日期：2020-01-24 00:00:00

abstract：:A triplet repeat expansion leading to transcriptional silencing of the FMR1 gene results in fragile X syndrome (FXS), which is a common cause of inherited intellectual disability and autism. Phenotypic variation requires personalized treatment approaches and hampers clinical trials in FXS. We searched for microRNA (mi...

journal_title：Cells

authors： Putkonen N,Laiho A,Ethell D,Pursiheimo J,Anttonen AK,Pitkonen J,Gentile AM,de Diego-Otero Y,Castrén ML

更新日期：2020-01-24 00:00:00

abstract：:The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...

journal_title：Cells

authors： Collins I,Wann AKT

更新日期：2020-01-23 00:00:00

abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...

journal_title：Cells

authors： Fraschini R

更新日期：2020-01-22 00:00:00

abstract：:Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bac...

journal_title：Cells

authors： Zhou X,Yang G,Guan F

更新日期：2020-01-22 00:00:00